Due to the multiplicity of aberrant phenotypes this strain was subsequently selected for further phenotypic analysis to evaluate whether changes in gene expression could be related to the altered phenotype.
The idea that altered DNA methylation plays a variety of roles in carcinogenesis is compatible with three key features of this multistage process: clonal selection of abnormal cells in a progressive fashion, the reversibility of tumor promotion, and the multiplicity of tumor phenotypes.
This may reflect the one-dimensionality of the nmo phenotype, degree of rotation, as opposed to the multiplicity of the tissue polarity phenotypes.
This intermediate phenotype of partially reconstituted rats is quantitatively comparable to the intermediate mammary carcinoma multiplicity phenotype of rats that are genetically heterozygous for the Mcs5a-resistant allele [ 5].
Because progeny tests indicated that B6.SNVg does not dominantly affect the tumor multiplicity phenotype of B6- Apc Min, we have developed a mapping panel of SNV sites in this line.
The number of progeny needed to detect a Generation 1 carrier of an ENU-induced modifier at power 0.9 was estimated from the standard, overdistributed tumor multiplicity phenotype of B6- ApcMin/+ (File S2).
Owing to the high multiplicity of infection and the diversity of MSP-142 phenotypes in Kenya (unpublished data), immunity conferred by the study vaccine may be directed to a minor parasite population.
