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This multiplicity of cellular functions is reflected in the variable pattern of localization of this protein in the nucleus [ 44, 45].
Similar conclusions were recently expressed by Drachman (2006) with respect to the multiplicity of cellular and molecular mechanisms that contribute to senescence in the human brain.
In conclusion, a shift of the external pH seems to act on various levels and affects a multiplicity of cellular processes finally limiting growth at non optimal pH conditions.
As eIF2 α phosphorylation on serine 51 is the convergent response to a multiplicity of cellular stresses including those induced by nutritional means, we investigated subsequently the kinases involved in this upregulation.
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Coinfected wild-type plants were probably not observed because the low cellular multiplicity of infection of TEV in N. tabacum (Tromas et al. 2014) precludes cellular coinfection, especially early in infection.
Therefore a cellular multiplicity of infection of 1 1 was used for mixing host and pathogen RNA, resulting in a ratio of 1000 1 total RNA, derived from the proportion of RNA abundance per cell between host and pathogen.
The multiplicity of potential genetic and cellular targets would provide support to the very high efficiency of MAV1 (N) which can induce 100% nephroblastomas within a 8-week period of time post injection.
A major action of CRF is the control of ACTH secretion, which in turn increases the production of cortisol, which produces a multiplicity of different responses dependent upon cellular identity [3].
The interaction of CCN3 protein with numerous potential partners could explain the multiplicity of functional implications of CCN3 in cellular calcium signaling.
Cellular nucleus contains a multiplicity of long and short ncRNAs controlling at different levels transcriptional and epigenetic processes.
This multiplicity of actions is supported by its numerous interactors, which comprise proteins implicated in membrane traffic, signaling and actin regulation in a variety of cellular compartments (Pirruccello and De Camilli, 2012).
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