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The resulting MDL file contains all atoms, their connectivity and multiplicity information.
We applied estMOI to sequence data for 54 clinical isolates from west Africa, where multiplicity information using MSP1 and MSP2 genotyping was available (Amambua-Ngwa et al., 2012).
This tool can rapidly search for potential MTIs and it is the first to provide multiplicity information and functional type (cleavage or translation) determined by the occurrence of a mismatch in central region (9-11nt).
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Organizing the multiplicity of information available in a renal biopsy to maximize benefits to the patient, as well as to the epidemiologist and researcher, is one of the challenges that face the nephrology community.
The multiplicity of information sources allows us to assume that nearly all newly diagnosed cancers are recorded.
The extent of multiplicity of data identified in trial reports is a function of the information provided in the review protocols: we would expect a poorly specified outcome to increase multiplicity.
Our results show that reporting cesarean rates by gestational age and multiplicity provides useful additional information for countries seeking to understand and compare cesarean practices.
The most comprehensive description is provided by a modified graph of the underlying net topology of an HBS which contains information on the multiplicity of links, the directionality and chemical connectivity of hydrogen bonds and on symmetry relations.
The multiplicity of an alignment yields information on the repetitiveness of a genomic region.
Also, by retaining spatial information concerning the multiplicity of the microcolony, the data can be used to correlate apoptotic scores with Bcl-2 scores directly and in relation to microcolony size (a good indicator of likely survival).
In summary, the current functional enrichment methods for miRNA cluster have limitations of not considering the tri-partite network topologies from miRNAs to genes to functional annotations regarding multiplicity and cooperativity, containing more information than simple target gene counts.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com