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Both gene- and pathway-based analysis deal with the challenge of multiple testing error control (i.e. multiplicity correction ).
Statistical significance of each predictor is assessed by the Bonferroni multiplicity correction to account for the effect of multiple testing.
After multiplicity correction, only working memory was associated with work/education outcome.
The average performance with two-sided confidence limits are plotted as derived by the Student t-test with Bonferroni multiplicity correction.
We show the average performance value (dot) with two-sided confidence limits as computed by Student t test with Bonferroni multiplicity correction.
The resulting method for Multilevel Inference of SNP Associations, MISA, allows computation of multilevel posterior probabilities and Bayes factors at the global, gene and SNP level, with the prior distribution on SNP inclusion in the model providing an intrinsic multiplicity correction.
Similar(32)
Statistical analysis (Wilcoxon test with Benjamini-Hochberg multiplicity corrections) revealed different expression or activation of 9 proteins between the MLL-rearranged patients and the non-translocated ones.
Statistical analyses (two-sample Welch t-statistics -unequal variances- with Bonferroni multiplicity corrections) revealed that in PGR patients the inhibited form of the kinase LCK (LCK phosphorylated at Y505) was higher than in PPR patients (p = 0.0388) (Figure 3A).
Multiplicity corrections were adopted to control false positives using Holm's method.
Our study has several limitations aside from the small cohort size and lack of multiplicity corrections for exploratory outcomes.
Moreover, the small entity of the expression changes observed with high dilutions unavoidably reduced statistical inference in the single genes, especially since multiplicity corrections were applied.
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