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For other secondary efficacy end points, pairwise p-values will be reported without multiplicity control.
This implementation of multiplicity control preserves more power as k increases and as the testing burden is consequently reduced.
Last but not least, an important consideration in outcome studies is around multiplicity control for primary endpoints and other secondary endpoints.
This was not due to off-target effects, as we observed exactly the same phenotype with the multiplicity control; siRNA oligos targeting other sequences within the PAG molecule.
To address those objectives and make formal statistical inferences from the data, one would need a testing strategy to have proper multiplicity control.
SNVer provides multiplicity control, and we performed Bonferroni correction and controlled the family-wise error rate at the 0.05 level to report identified SNVs.
Similar(51)
The multiplicity of control mechanisms of ECM protease activity, of which transcription regulation is only one of importance, compartmentalization by pericellular accumulation, activation by cleavage of latent pro-enzymes and inhibition by specific proteins being the others [ 7, 8].
Two sample t-tests using the −ΔCT values were performed; Holm's method was applied to adjust for multiplicity and control the overall family-wise type I error rate at α=0.05.
The impact of steady-state multiplicities on control structure design is highlighted.
The important consequences of p53 activity, potentially cell death or tumor promotion, require this fineness and multiplicity of controls.
Multiplicity was controlled for the primary endpoint by a sequential procedure where GP MDI 115.2 μg was first compared with Placebo MDI using a two-sided alpha level of 5%.
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