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Exact(6)

Treatments with 2-hydroxy estradiol alone or in combination with progesterone did not affect cancer multiplicity compared with the controls (Table 3).

Interestingly, even though tamoxifen treatment had a greater effect on the body weights of ovariectomized rats, this was not associated with a reduction in tumor multiplicity compared with control rats.

The BR males had a moderate susceptibility with an average of 27 liver tumors, a 7-fold increase in tumor multiplicity compared with the average of four tumors in resistant B6 males (P = 2 × 10−7).

In the ovariectomized model, where tumors are hormonally nonresponsive, tamoxifen treatment had no significant effect on tumor multiplicity compared with the control groups (Table 1 and Figure 1b,d).

The overall analysis showed that the colon mucosa of G2, which had the highest values of tumor incidence and tumor multiplicity compared with other groups [ 16], displayed the highest β-catenin protein expression in the western blotting evaluation compared with the other treatment groups.

Males from the recombinant lines that exhibited susceptibility in females showed between 25 and 39 liver tumors on average, a 1.5- to 2-fold increase in liver tumor multiplicity compared with B6 siblings, also wholly recapitulating the effect of the full-length congenic region.

Similar(54)

The DEN+CQ-treated rats, which were injected with CQ throughout the whole process of hepatoma development (from 0 to 17th week), had similar tumor incidence, maximum volume of tumor nodules and tumor multiplicity as compared with those of the DEN-treated group at 14 and 17 weeks (data not shown).

Il10−/− mice mono-associated with the mildly colitogenic bacterium Bacteroides vulgatus displayed significantly reduced colitis and colorectal tumor multiplicity compared to Il10−/− mice.

Concordant with inflammation status, mono-associated Il10−/− mice displayed a significantly lower tumor multiplicity compared to their conventionalized counterparts (0.4 and 2.3 respectively, p = 0.002) (Figure 6B).

Vaccines significantly decreased tumor multiplicity compared to controls (P < 0.05 by Student's t-test).

Theoretical prediction for multiplicity are further compared with multiplicity data reported in literatures.

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