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As shown in Fig. 2B, AOM-treated Il10−/− mice showed a dramatic increase in tumor penetrance and multiplicity compared to WT mice.
Herein, we show that jnk2 knockout mice expressing the Polyoma Middle T Antigen transgene developed mammary tumors earlier and experienced higher tumor multiplicity compared to jnk2 wildtype mice.
Il10−/− mice mono-associated with the mildly colitogenic bacterium Bacteroides vulgatus displayed significantly reduced colitis and colorectal tumor multiplicity compared to Il10−/− mice.
Concordant with inflammation status, mono-associated Il10−/− mice displayed a significantly lower tumor multiplicity compared to their conventionalized counterparts (0.4 and 2.3 respectively, p = 0.002) (Figure 6B).
Vaccines significantly decreased tumor multiplicity compared to controls (P < 0.05 by Student's t-test).
Administration of 40% (w/w) of brewers' rice significantly reduced tumor multiplicity compared to the AOM-alone group (P<0.05).
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The two stage carcinogenesis protocol showed that K5-VILIP-1 mice had a 49% decrease in the SCC tumor multiplicity when compared to WT mice at week 30 (p<0.02) (Figure 4A).
Fennel seeds exhibit a significant reduction in the skin and the fore-stomach tumor incidence and tumor multiplicity as compared to the control group.
Magnolol pretreated groups (30, 60 μ g) before UVB treatments (30 mJ/cm, 5 days/week) resulted in 27-55% reduction in tumor multiplicity as compared to control group in SKH-1 mice.
For example, Grivennikov and co-workers demonstrate that Il6−/− mice exhibit decreased tumor multiplicity and load compared to WT mice after AOM/DSS treatment yet these mice displayed more severe intestinal inflammation than WT mice.
Their symmetry, spin multiplicity, and energy difference compared to each of the most stable structures are also indicated in the figure.
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