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Additionally, the corresponding multiplicative interactive effects were estimated with 99% confidence intervals.
Departure from a common, fully adjusted, relative effect model in important subgroups was investigated by adding a multiplicative interactive term (a × b) based on road noise exposure (a; continuous) and the investigated subgroup variable (b; categorical).
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We found an expected multiplicative interaction between parameters.
"How Much Should We Trust Estimates from Multiplicative Interaction Models?
With regard to evaluation of the interactive effects of SNPs and dietary intakes on breast cancer risk, the combined effects of SNPs and dietary intakes were assessed by adding the multiplicative interaction product (genotype × dietary intake) to the final model as indicator variables.
*Indicates a multiplicative interaction term.
Association between both genetic (i.e., one of the MUTYH mutations) and the study code or environmental factor (i.e., HRT) and disease was assessed and interaction was tested by fitting interactive and nested multiplicative models.
A subsequent review of this literature suggested that the interactive effects are multiplicative [ 14], which implies that asbestos exposure increases the risk of lung cancer by the same factor in smokers and non-smokers alike.
We observed the presence of an interaction on a multiplicative scale with an OR (95%CI) of 2.24 (1.27 3.95) (p = 0.005) and a slight interactive effect between the two haplotypes on an additive scale with an OR (95%CI) of 1.56 (1.02–2.37) (p = 0.03) and S of 1.66 (0.89–31.66
The presence of an interaction on a multiplicative scale may reflect the role of other genes and/or environmental factors that participate in the same metabolic pathway and are therefore indirectly involved in determining the observed interactive effect.
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