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The global null hypothesis of no association between haplotype frequency (by haplotype block) and cancer was tested, by comparing a model with multiplicative effects for each common haplotype (treating the most common haplotype as the referent) to the intercept-only model.
Sample size is estimated for the secondary outcome (failure of patency at 6 months) under assumptions of additive or multiplicative effects for each of 3 placebo rates.
Our main interest was in a model that could estimate additive effects for gender, pack-years, and their interaction, considering multiplicative effects for all remaining covariates.
Results from regression models in which the log of PFOA was the outcome were transformed back to the original unlogged scale, resulting in multiplicative effects for predictor variables.
The evidence for a combination of independent multiplicative effects for BMI and activity seen in our study and in particular the absence of any negative interactions emphasizes the potential public health importance of joint exposure to high BMI and high activity stressors.
We used unconditional logistic regression to test the global null hypothesis of no association between haplotype frequency and breast cancer, by comparing a model with multiplicative effects for each common haplotype (treating the most common haplotype as referent) to the intercept-only model.
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The Pokémon brand offers a multiplicative effect for the potential growth of an app, but the game still has to be good.
We identified regions with a putative multiplicative effect for all traits.
Despite near-multiplicative effects for most loci, and the fact that groups with very high relative risk of type 1 diabetes can be identified by testing for multiple susceptibility genes, only a small proportion of the population (and cases with type 1 diabetes) simultaneously carry HLA and multiple non -HLA susceptibility genotypes.
Additive or multiplicative effects of combined genetic variants for different DNA-repair pathways have been previously reported for lung cancer [ 32], melanoma [ 33] and breast cancer [ 34].
After controlling for the multiplicative effects of a prolonged rural undergraduate experience during clinical training and previous rural background, no predictive value was seen for either prior academic performance at secondary school or for score on a standardised interview.
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