Sentence examples for multiplex mutations from inspiring English sources

Our study provided a novel and efficient approach to simultaneously introduce multiplex mutations in situ, which is a potential strategy for target enzyme evolution in vivo.

The distinct advantage of FMCA lies in its capability of multiplex mutation detection [27].

We conclude that the performance of the two multiplex mutation assays was superior to direct sequencing.

10 A multiplex mutation detecting kit using Luminex technology (Mebgen Rasket Kit; Medical and Biological Laboratories, Nagoya, Japan) has been approved for the simultaneous detection of 48 types of RAS mutations.

Mutation analysis was performed by multiplex amplification refractory mutation system (M-ARMS), direct DNA sequencing of beta-globin gene, and gap polymerase chain reaction for 3.4 kb deletion detection, respectively.

Genotyping of APOE was determined by multiplex amplification refractory mutation system polymerase chain reaction.

The APOE genotypes were determined by multiplex amplification refractory mutation system polymerase chain reaction according to the method previously described.

We have established a multiplex 'amplification refractory mutation system' (ARMS) based method for the identification of prnp 136-154-171 genotypesheepsheep.

We examined the feasibility of analysing DNA extracted from FFPE ovarian and breast tumour tissue to identify significant DNA variants in BRCA1/ BRCA2 using next generation sequencing methods that were sensitive enough to detect low level mutations, multiplexed to reduce the amount of DNA required and had short amplicon design.

In addition, multiplex testing for driver mutations in 72 squamous cell carcinomas of the lung detected: PIK3CA mutations in 8%, PTEN mutation/deletion in 28%, FGFR1 amplification in 26%, and unknown genetic alterations in 39% [ 9].

Here we examined whether HRRA can detect such a recessive mutation when only a small proportion of multiplex families carries the mutation haplotype.