Sentence examples for multiple xenograft models from inspiring English sources
Complete eradication of WT in multiple xenograft models was achieved with a human NCAM antibody drug conjugate.
Previous studies from this laboratory demonstrated specific, high efficiency targeting of panitumumab in HER1-positive tumors in multiple xenograft models.
When the drug was administered in combination, it can block tumor formation in multiple xenograft models where DNA-damaging agents alone cannot [ 56].
In multiple xenograft models, administration of INK128 alone or in combination with other standard targeted therapy or chemotherapy resulted in antiangiogenic and tumor growth inhibitory effects [107].
Moreover, we have demonstrated that ADCs against SAIL have high in vitro potency and demonstrate high antitumor activity in vivo in multiple xenograft models.
Induction of histone hyperacetylation and apopotosis have been shown as well as antiproliferative activities against a wide panel of tumor cell lines and tumor growth inhibition in multiple xenograft models (Fournel et al. 2008; see Fig. 4).
Further optimization of 7i to balance biochemical and cellular potencies with favorable ADME/ PK properties led to the identification of 8h, a compound with a clean CYP profile, acceptable pharmacokinetic and toxicity profiles, and robust efficacy in multiple xenograft tumor models.
Bosutinib, identified as a SRC kinase inhibitor, is effective in preventing de-differentiation, reducing tumor growth, invasion and distant metastasis in multiple xenograft tumor models (21– 21).
HGS-ETR1 had an effective pharmacokinetic half-life, and induced rapid tumour regression in multiple xenograft tumour models alone and in combination with chemotherapeutic agents.
In particular, in our chicken multiple myeloma xenograft models we were able to demonstrate potent antiangiogenic and antimyeloma activities of both Aplidin analogs in sublethal concentrations.
Indeed, both PERK [ 73] and IRE1 [ 70] inhibitors are cytotoxic to cancer cells and have shown activity in multiple myeloma xenograft models.
