Renal involvement in monoclonal gammopathy and multiple myeloma is well described and the most common is tubular damage by light chain cast nephropathy (myeloma kidney) and glomerular damage through amyloidosis or light chain deposition disease (LCDD).
While the cellular events associated with ciliogenesis of solitary 9+0 primary cilia and multiple 9+2 cilia are well described, that of multiple 9+0 cilia in CPECs was totally unknown.
Additionally, although factors associated with the development of idiopathic frozen shoulder have been well described, multiple studies looking at predictors of postoperative stiff shoulder have produced conflicting results.
Although the epidemiology and progression of multiple organ failure are well described, it is not possible to conduct detailed and reliable analyses of the temporal relations between failing organs and the effects of interventions (for instance, institution of antibiotic therapy or surgery).
Although many risk factors for melanoma are well described, their multiple interactions make risk prediction complex.
The paper is very well written and easy to understand, the experiments are appropriate and well described, and multiple approaches are used to confirm each result.
Cortical atrophy is well described in multiple sclerosis, even in the early stages of the disease (Sailer et al., 2003; Dalton, 2004; Calabrese et al., 2007; Amato et al., 2012).
The presence of multiple SSc-associated autoantibodies has been well described [ 12- 15].
This adenoma-carcinoma sequence leading to CC is well described, and is characterized by multiple genetic and epigenetic events [ 29].
Phenotypic and genotypic heterogeneity in Barrett's tissue has been well described, 4 5 8 including patients with multiple distinct p53 point mutations.
