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For both multiple wavelet and mother rotor VF, cardiac heterogeneity plays an important role.
Figure 5 shows ECG and period distributions for both multiple wavelet and mother rotor simulations.
This is shown in Supplemental Fig. 5 for both the multiple wavelet and mother rotor fibrillation simulations.
Interestingly, our simulations show that multiple wavelet and mother rotor VF can occur in the same heart, depending on the initial location of the spiral.
Two of the most frequently discussed mechanisms observed in experiments with animal hearts are the multiple wavelet and mother rotor hypotheses.
Supplemental Figure 3 shows the corresponding 3-D spatial distribution of mean period values for the multiple wavelet and mother rotor simulation measured between 2 4 and 4 6 s, respectively.
Similar(53)
The onset of VF is believed to be associated with the break-up of spiral waves or rotors into multiple wavelets and oscillations in electrical activity [ 61].
However, it should be emphasized that any type of heterogeneity, i.e., from local dynamic or fixed heterogeneities (including APD restitution), favors the formation of local wavebreaks and thus provides a substrate to sustain VF of any type (e.g., multiple wavelets) and not exclusively mother rotor VF.
By defining Besov balls in multiple wavelet domains and projecting onto their intersection using the projection onto convex sets (POCSs) algorithm, an estimate is obtained in [20], which effectively combine estimates from multiple wavelet domains.
The first type of VF dynamics we found was multiple wavelet VF, and this was investigated in our previous publication (23).
ECG signals for mother rotor and multiple wavelet VF were similar and resembled clinically observed ECG signals during VF.
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