Sentence examples for multiple viral targets from inspiring English sources
The present study suggests a co-cultivation technique for production of antiviral dsRNA with multiple viral targets.
In addition to compatibility with Pol II promoters, pri-miR sequences may be multimerized to enable simultaneous silencing at multiple viral targets.
Targeting multiple viral targets by dsRNA could possibly result in additive inhibition; however, more importantly, this approach should lower the chance of viral escape that needs to have multiple resistance mutations within the dsRNA targets occurred simultaneously [ 16].
In addition, as with other viruses, when only one RNAi is targeted escape mutants can be generated [ 157]; targeting multiple viral targets, combinations of host and viral proteins, even combining host, viral proteins, and clinically approved antiretroviral drugs have demonstrated improved efficacy against HIV [ 152, 158– 158].
Several reports already validate this new concept of "combinatorial RNAi" (coRNAi) and illustrate its versatility by describing co-expression of RNAi triggers directed against single or multiple, viral or cellular, targets.
Influenza-specific CD8+ T cells recognize multiple viral epitopes on target cells and antigen-presenting cells.
As well as targeting multiple HCV epitopes, an effective global vaccine will also need to target multiple viral genotypes [14].
A major goal of developing anti-HIV-1 RNAi therapy is to target HIV-1 in a manner that prevents viral escape; such strategies may include targeting multiple viral sites and endogenous host factors that are required for HIV-1 infection and replication.
Cocktails of mAbs and bispecific constructs can be used to simultaneously target multiple viral epitopes and to overcome issues of neutralization escape.
Targeting multiple viral antigens, in this case NP and M2, clearly has advantages over using a single antigen.
In turn this suggests that the generation of broader responses that target multiple viral epitopes may be critical to the development of effective protection against AIDS.
