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Finally, mammalian adaptation of the H9N2 viruses could possibly have involved multiple viral genes.
In any case, the presence of multiple viral genes that cooperatively antagonize the IFNα/β response is not uncommon among the different virus families.
Lytic manipulation of these cell lines facilitates efficient detection of multiple viral genes not detected during latency, and also validates the detection of specific novel viral genes.
Virtually all cases of NPC show genetic positivity for EBV, with multiple viral genes being expressed in each tumor cell [8].
This approach can be used as a part of a combinatorial RNAi (co-RNAi) strategy for highly effective simultaneous suppression of multiple viral genes preventing the possibility of mutation-assisted escape from RNAi.
In conclusion, the present study provides the first evidence that the highly stable plant MIR2911 can directly target multiple viral genes of various IAVs and thus suppress viral infections.
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"Efficient transmission of influenza virus results from synergism among multiple viral gene segments," she says.
Successes have been reported with RNAi technology using either single or multiple viral gene sequences, or by artificial miRNA [ 27- 29].
The KSHV latent locus encodes multiple viral latent genes, including LANA (ORF73), vCyclin (ORF72), vFLIP (ORF71 or K13), all viral miRNAs and kaposin (K12).
Z protein, encoded by viral BZLF1 gene, is a potent transactivator of multiple viral and cellular genes critical for switching from latent to lytic cycle.
Lateral exchange of viral genes, via multiple possible mechanisms, is rampant among viruses within each of these principal types, but is generally confined to closely related viruses, or viruses (and plasmids) with similar replication mechanisms [ 13- 20].
More suggestions(15)
multiple viral sources
multiple viral epitopes
multiple viral variants
multiple viral antigens
multiple viral proteins
multiple viral vectors
multiple viral siRNAs
multiple viral coinfections
multiple viral families
multiple viral genotypes
multiple viral haplotypes
multiple viral species
multiple viral infections
multiple viral particles
multiple viral pathogens
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