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However, the presence of multiple vascular risk factors was associated with CVC.
They are indeed mainly related to the aging process and multiple vascular risk factors, such as hypertension, elevated BMI, hypercholesterolemia and diabetes [48 52].
Hence, it is not possible to conclude whether the study results are generalizable to patients who have multiple vascular risk factors or obvious secondary causes of RCVS, such as illicit drug users.
It is unclear how multiple vascular risk factor exposures (polyvascular disease) affect VaD.
They then adjusted all multivariate models for multiple vascular risk factors, to increase the likelihood of observing apoE-dependent effects.
To determine the relationship between multiple vascular risk exposures, as counted on an index in cases with VaD, compared with healthy age-/gender-matched controls.
Similar(48)
Also notable is the lack of influence of including eGFR < 60 ml/min/1.73 m2 as a covariate in models where CHD was the dependent variable, which may suggest that renal dysfunction has a weaker association with CHD in type 2 diabetes (who have often have multiple overlapping vascular risk factors) than in non-diabetic populations.
Polyvascular disease is the accumulation of multiple vascular diseases or risk factors, including the addition of coronary artery disease and peripheral artery disease.
However, it has been argued that, because of the cumulative effect of multiple risk factors, vascular risk would be best managed using multi-factorial estimates of absolute risk based on established risk estimators such as the Framingham equations for estimating cardiovascular risk [ 12, 13].
The results of the REACH study shed some light on the role of multiple vascular illnesses or risks with the development of VaD.
The results of our study are novel; however, they fit within the theme of multiple vascular illnesses having a higher risk of major vascular events.
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