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HIV-and SIV infection are characterized by the presence of multiple variants within individuals [6] [9].
Genetic analysis of these isolates showed evidence of multiple variants within single specimens (20 ).
The approach is based on considering multiple variants within a gene jointly.
Several rely on capturing multiple variants within each locus (50– 52) or require densely genotyped data (53, 54).
Variation in quantitative traits includes additive, dominant, and epistatic effects that are conferred by multiple variants within interactive genes in different biological pathways.
Therefore, lithium response is apparently polygenic and only by simultaneously examining multiple genes and multiple variants within these genes would it be possible to provide some guidelines for predicting the response.
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Several studies have identified multiple variants (rs2732552, rs507230) within or nearby CD44 that are associated with SLE in various populations [ 45, 46].
The most recent study also revealed that using the major variants alone is sufficient for phylogeny construction and species determination in most cases although intragenomic multiple variants are frequently found within each genome.
We provide a general framework for association testing with rare variants by combining mutation information across multiple variant sites within a gene and relating the enriched genetic information to disease phenotypes through appropriate regression models.
Instead of examining the association of each rare variant in isolation, multivariate methods that combine information across multiple variant sites within a gene or other functional genomic region are a viable alternative strategy (Fig. 1).
However, as noted above, diversity has been observed to evolve within each spatial niche: multiple variants of each morphoytpe are commonly present within evolved populations.
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