Sentence examples for multiple variants in from inspiring English sources
On this interpretation, each eQTL (or GWAS) effect is actually the summation of very mild contributions from multiple variants in the interval.
Traditional approaches rely on protein expression trials of multiple variants in various systems, frequently with limited success.
Since these traits are likely influenced by the joint effect of multiple variants in a gene, a joint analysis of these variants considering linkage disequilibrium (LD) may help to explain additional phenotypic variation.
This study provides evidence for association of multiple variants in the KCNN3 ion channel gene with migraine susceptibility in a large multigenerational pedigree from the unique Norfolk Island genetic isolate.
We hypothesized that multiple variants in genes in the same pathway may jointly contribute to the association with disease status.
We observed multiple variants in the potential pathway of the IL10 gene family, contributing individually or jointly to the heterogeneity in HIV-1 pathogenesis.
Therefore, it is possible that this approach will result in multiple variants segregating in one family, all playing a role for the pathogenicity in that family.
Like other similarity-based methods (e.g., SIMreg and SKAT), the new method has the advantages of avoiding the need to specify thresholds for rare variants and allowing for testing multiple variants acting in different directions and magnitude of effects.
If multiple variants segregating in a population are concurrently driven to intermediate frequency by positive selection, the variation tightly linked to these variants will also tend to occur at intermediate frequencies, thus generating a skew in the frequency spectrum.
Prioritization of which of the multiple variants listed in the SNP database to study was informed by protein structural information, but remained relatively simplistic.
This definition encompasses both Mendelian and multigenic complex diseases, and at present probably focuses most on single Mendelian variants of large effect, although emphasis is expected to shift soon to assaying and using multiple variants simultaneously in clinical care.
