In groups that did show an effect, multiple vaccinations were required (>10), at a dose of 25 μg, and it is thought that the disease stage can apparently modulate efficacy, and also the amount of available tumour tissue available to work with will vary with disease stage [ 87– 87].
Every opportunity should be used to vaccinate and accelerated schedules and multiple vaccinations may be used to avoid further delay in children who have missed out of previous vaccination opportunities.
Human vaccination for avian influenza viruses has not been widely used, although multiple vaccination trials are underway.
This low response might provide insights useful for potential vaccine development against subtype H7N9; multiple vaccinations might be needed to achieve protective immunity.
In two randomised trials the GM-CSF-containing arms did worse than the vaccine-alone arms [7,8], again indicating that multiple vaccinations might be harmful.
Furthermore, probably multiple vaccinations will be necessary to evoke an adequate immune response, because the immune system of these very young infants is not optimally operating (immature).
If technically and ethically feasible, additional animal experiments using multiple vaccinations may be helpful to confirm these predictions.
Most schools had more than one class of girls in grade 6, so multiple vaccinations sessions were run on the day of vaccination.
Because of the relatively weak protective antibody response to influenza A(H7N9), multiple vaccinations might be needed to achieve protective immunity.
