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To date only few data exist on the predictive values of multiple urine markers in this negative-cystoscopy setting.
A comparison of multiple urine markers and their combination has not been performed yet with regards to their anticipatory role.
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Urine markers have been studied extensively but there is a lack of blood prognostic markers in bladder cancer.
Urine markers have been studied extensively but cannot be easily standardized due to diuresis variations, and blood prognostic markers for bladder cancer are lacking.
This might be a key reason that there are no reliable urine markers for cancer diagnosis.
Urine markers were performed as previously described [ 10].
However, it is also known that the variability of SF markers is greater than for serum and urine markers [ 32].
Further studies with more sensitive urine markers, bone density assays, and longer follow-up are warranted.
Therefore, the effect of anticipatory-positive urine markers could not be addressed [ 25].
Urine markers are considered to be a valuable adjunct to cystoscopy [ 17, 18].
Several reports indicate that anticipatory positive urine markers may indeed precede clinical tumor recurrence.
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