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None of these were considered to be related to study medication and all four patients had multiple underlying comorbidities including prior cardiac failure, coronary artery disease and hypertension.
Although bypass surgery remains the cornerstone of CLI treatment, the majority of the patients are rendered ineligible because of diffuse infrapopliteal arterial occlusions, absence of suitable vein grafts and multiple underlying comorbidities.
Interventional radiological percutaneous procedures are becoming all the more important in the curative or palliative management of elderly frail patients with multiple underlying comorbidities.
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Probably, other factors such as requirement for mechanical ventilation, length of stay in intensive care unit, multiple organ dysfunction, and underlying comorbidities contributed to longer hospital stays and could be important determinants other than prophylactic antibiotic administration.
Exclusion criteria were: (1) age <20 years, (2) malignancies with poor prognosis within 5 years and (3) significant underlying comorbidities or severe multiple organ failure refractory to treatment (4) mortality within 24 h after ECMO initiation.
The Charlson comorbidity index with its 17 comorbid disease categories [13] was used to assess the presence of underlying comorbidities.
Information on underlying comorbidities was collected by chart review.
Additionally, underlying comorbidities including CKD and heart failure further limit the range of renal capacity.
Patient factors included nature of acute illness, underlying comorbidities, clinical presentation, and patient's values.
The elderly, smokers and persons with underlying comorbidities with human influenza infection are at increased risk of a fatal outcome.
Underlying comorbidities were present in 179 patients (89%).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com