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Targeting of mitotic cells is one of the bases of therapy for patients with multiple types of solid tumors.
Small populations of cancer cells within multiple types of solid tumors have been identified based on cell surface marker expression and other phenotypic and functional characteristics.
The primary tumor F/B is also prognostic in stage I colon adenocarcinoma, suggesting this assay may be useful in multiple types of solid tumors.
Sphere-forming assays have been commonly used to retrospectively identify normal and cancer stem cells, and measure stem cell/early progenitor activity in multiple types of solid cancers [ 38, 63, 64].
Individual cancer types within TCGA comprise too few patients to attempt large scale association analysis, however as somatic mutation of the EGFR pathway is a hallmark of multiple types of solid cancer types, we sought to maximize the power of our study by combining patients across multiple cancer types that exhibit high frequency of mutation in the EGFR pathway.
In particular, the miR-17-92 miR-17-92 miR-17-92six micluster all encoded by the same grouphas been studied extensively since researchers first discofered that it isixverexpressed in Burkitt's lymicroRNAsiffuse B-cell lymphomallnd multiplencoded of solid tumours (Ota et al., 2004).
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A recent study reported that miR-30d was amplified in more than 30% of multiple types of human solid tumors [ 26], suggesting a therapeutic role of the platinums in these cancers.
Additionally, multiple types of in situ carcinomas, such as solid, cribiform, papillary and comedo types, have been reported and it is possible that these represent tumors originating from different epithelial subtype [ 16, 17].
Among the multiple types of CSCs that have been identified in distinct solid tumors, Oct-4-positive CSCs are associated with high-grade and poor prognosis tumors.
Extensive numerical experiments are presented for several flow problems involving multiple fluid components and solid-wall boundaries to investigate the wettability effects with multiple types of contact angles.
There are multiple types of fuel cell technologies that are being pursued that include proton exchange membrane fuel cells (PEMFCs), solid oxide fuel cells (SOFCs), direct methanol fuel cells (DMFCs), and microbial fuel cells (MFCs) to name a few.
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