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Proteins can be ubiquitinated with multiple types including monoubiquitination and polyubiquitination, and degraded in the lysosome or the proteasome, respectively.

However, more recently it has been clearly demonstrated that VEGFR-3 expression is upregulated on the blood vessels within tumours of multiple types including melanoma, colon and breast (Valtola et al, 1999; Achen et al, 2001; White et al, 2002).

CXCR4, the receptor of the chemokine CXCL12/SDF-1, is expressed in many tumours of multiple types including mammary (Muller et al, 2001), colon (Zeelenberg et al, 2003) and pancreatic (Saur et al, 2005) carcinoma, melanoma (Scala et al, 2005) and brain tumours (Rubin et al, 2003).

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UTX mutations were first described by van Haaften et al. in multiple cancer types, including multiple myeloma, gastrointestinal cancers and myeloid leukemias.

In 2009, somatic loss-of-function mutations and deletions targeting the UTX gene were identified in multiple cancer types including multiple myeloma, esophageal and renal cancer.

NCCs have the potential to differentiate into multiple cell types, including cartilage, vascular SMC and peripheral neurons, which involves multiple signaling pathways, including TGFβ2 and BMP signaling [ 1].

The FGFR pathway is involved in multiple cellular processes, and research has shown that aberrant pathway amplification is observed in multiple tumor types, including breast cancer.

Wearables obviously covers multiple device types, including smartwatches, fitness & activity trackers, people monitoring & safety devices and medical devices.

In those 18 patients with multiple headache types including CM, the median follow-up time was 45.00 months (range 17 87).

This progress is evidenced by the vascularization of multiple tissue types including bone, muscle, cardiac, pancreas, etc.

This emerging strategy has been used in unique ways to target multiple tumor types, including solid and haematological malignancies.

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