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Multiple tumours with a pathological uptake are present in the liver (L) Fig. 2 Mean absorbed doses to the spleen per 7.4 GBq of 177Lu-DOTATATE for the different fractions.
Multiple tumours with the same histologic type appearing in the breast and in a different site are regarded as multiple primary tumours unless stated as metastatic tumours.
Simultaneous multiple tumours with the same histologic type within the breast are regarded as a single tumour, and even when different tumours have different behaviour codes.
For the MMTV-PyMT model growing orthotopically or in the transgenic animals, due to the presence of multiple tumours with divergent IFP values in each animal, metastases data are plotted according to the mean IFP value of all the tumours within that animal.
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Neurologists and obstetricians in the city interviewed by the Guardian say the rise in birth defects — which include a baby born with two heads, babies with multiple tumours, and others with nervous system problems — are unprecedented and at present unexplainable.
The cancer groups were then grouped into those patients with a clear primary cancer diagnosis, those with multiple tumours or those with no clear indication of the primary tumour site.
When using the subset-based approach (ASSET), rs7023329 showed suggestive association with multiple tumours (positive effect P=0.007), with the strongest signal obtained from the subset combining data from CRC, CA and OS studies (Table 2c).
Chromosomal analysis demonstrated a higher sensitivity to clastogens of HNCPs with multiple tumours than of HNCPs with a single cancer (P < 0.01), and a significant correlation between chromosome fragility and p53 overexpression (P < 0.01) only in HNCPs with multiple malignancies more than in those with single head and neck cancer (P = 0.11).
In addition to the development of multiple tumours, most individuals with TSC have seizures during childhood (often with onset in infancy), and about 50% of TSC patients have cognitive defects including autism and intellectual disability.
The IARC/IACR rules may undercount multiple tumours, because cancers with the same site and histology, diagnosed more than 2 months apart but excluded as a later primary, may actually represent a new tumour.
However, in patients with inherited conditions resulting in multiple tumours (such as those with Gorlin's syndrome), repeated surgical interventions may become untenable, and radiation therapy may be contraindicated because of the high risk of patients developing further BCCs (Leger et al, 2011).
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