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Including tumours occurring prior to gynecomastia 8 individuals of 9 had multiple tumours of the skin.
The genetic condition neurofibromatosis type 2 is characterized by formation of multiple tumours of the peripheral nervous system.
Multiple tumours of different histologic types within the breast are counted as multiple primary tumours regardless of time.
In addition to these cases, we excluded the tumours from a subject who had multiple tumours of two histologies and tumours from the 15 non-white subjects.
Multiple tumours of different histologic types appearing in the breast and in a different site are multiple primary tumours regardless of time (Fritz and Ries, 1998 ; Howe et al, 2003 ).
The cell line 84BR was derived from a clinically radiosensitive breast cancer patient, whereas the 175BR cell line was derived from a cancer patient with multiple tumours of independent histological origin.
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Chromosomal analysis demonstrated a higher sensitivity to clastogens of HNCPs with multiple tumours than of HNCPs with a single cancer (P < 0.01), and a significant correlation between chromosome fragility and p53 overexpression (P < 0.01) only in HNCPs with multiple malignancies more than in those with single head and neck cancer (P = 0.11).
Furthermore, in all of the patients who had multiple tumours, one of which was HER2+, the HER2+ tumour was also the highest-grade tumour and the tumour with the highest NPI.
The median age at the STS diagnosis was 66 (range 16 98) years and the median age at the first malignant diagnosis among patients with multiple tumours, irrespective of tumour type, was 69 (31 91) years.
Most of the methylated tumours (12 out of 12 solitary tumours and 7 out of 9 (78%) of multiple tumours) showed an apparent loss of hMLH1 protein expression.
Sex, age, tumour size, bilirubin, Child Pugh score, Okuda stage, CLIP stage, the presence of one or multiple tumours, the location of the tumour in the liver were all evaluated.
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