Sentence examples for multiple tumour suppressor from inspiring English sources

Krohn, A. et al. Recurrent deletion of 3p13 targets multiple tumour suppressor genes and defines a distinct subgroup of aggressive ERG fusion-positive prostate cancers.

This suggests that a phenomenon similar to that of the previously described BRCA-ness, wherein a miRNA, miR-182, has been shown to repress BRCA and confer sensitivity to PARP inhibitors in a subset of tumours38, may be at work within many cases, and across multiple tumour suppressor genes.

For example, hereditary melanoma is associated with a loss of function of the tumour suppressor gene called MTS1 (from multiple tumour suppressor), which also goes awry in a variety of sporadic tumours.

The frequent chromosome losses in these regions suggest that they harbor multiple tumour suppressor genes (TSG) [6] [8].

We decided the clonality in all multicentric tumours using MSP in multiple tumour suppressor genes.

Tumour clonality was determined by the methylation status of multiple tumour suppressor genes.

Epigenetic inactivation of multiple tumour-suppressor genes (TSGs) is a key molecular event in the multistep genetic pathogenesis of cancer.

A novel p73 gene, which is related to p53, has recently been identified and mapped to chromosome 1p36.3, which is a locus of multiple tumour-suppressor genes for many cancers, including hepatocellular carcinoma (HCC) and neuroblastoma.

As a result, tumour cell proliferation even following multiple oncogene and tumour suppressor gene mutations may be limited by regional variations in oxygen, glucose, and H+.

Disruption of the cellular processes involved in methylation could lead to concurrent hypermethylation of multiple genes, including tumour suppressor genes, and as a result lead to oncogenic transformation.

This conclusion is further supported by the finding of increased ER/PR and/or HER2 expression in IDC-DCIS, suggesting in turn that the pure IDC carcinogenesis pathway could favour the therapeutically challenging basaloid phenotype, which is already known to be associated with multiple defects in tumour suppressor genes such as TP53 and the BRCA DNA repair genes.