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Studies demonstrating the synergistic combination effect of SMAC mimetics and TRA further suggested potentially effective treatment in multiple tumour settings.
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A biopsy-based approach to multiple tumour lesions has practical limitations.
Hence, further studies are required to determine how B/M and particularly MPA or other AKR1C3 inhibitors exert anti tumour activities in different tumour settings.
Different mechanisms underlie this activation in different tumour settings.
Oncomine analysis demonstrated downregulation of expression in multiple tumour types.
This assumption was experimentally validated in several tumour settings (Fig 3A).
Further studies are needed to examine the interaction of the pathways in various tumour settings.
When multiple tumours were present, they were analysed separately.
Sixty percent of these cases present as multiple tumours [33].
Moreover, for patients with multiple tumours, an approximate tumour location was given by a range of slices where the tumour could be located.
One patient had multiple tumours in a non-cirrhotic liver (patient #5).
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