Sentence examples for multiple tumour samples from inspiring English sources

Mutation data from multiple tumour samples from a single patient were linked.

In 53 out of 187 patients multiple tumour samples (2 13 biopsies) were available for analysis.

Interestingly the detected variant allele frequencies were strikingly similar between multiple tumour samples from the same patient.

For patients with multiple tumour samples data on tumour type, treatment and course of disease were gathered from patient files.

In addition, running multiple tumour samples at once allows for manual inspection to discover samples that contained the alternative splicing pattern, and consequently, permits the identification of DNA mutations in the same location which went undetected during genome sequencing.

Exome sequencing of multiple tumour samples from primary and metastatic lesions in two patients with clear cell RCC revealed extensive intra-tumour heterogeneity, which was demonstrated in genetic and transcriptomic analyses.

Clinical data with respect to melanoma type, tumour site and survival were summarised for 53 patients with multiple analysed tumour samples (2 13 per patient).

While we cannot extrapolate this single patient observation to prostate cancer in general, this report describes powerful methodology to address this question in multiple prostate tumour samples, which is currently underway in our laboratory.

In our cohort of multiple spatially separated tumour samples, we found that HES5 expression was decreased in tumour cores compared with matched benign tissue and that HES6 was also increased in some of those tumour cores, consistent with HES5 silencing in tumourigenesis and additional mechanisms regulating HES6 expression (Supplementary Figure 5e and f).

We assessed the reproducibility and clonality of these eight differentially methylated regions in our cohort of cases with multiple spatially separate tumour samples, matched benign tissue and blood DNA samples (Fig. 1b and Supplementary Figure 1f, g, h, i, j, k, l, m).

Only two tumours homogeneously expressed the ccA signature; the other eight tumours were heterogeneous with ccA and ccB components detectable, suggesting the need to sample multiple tumour regions to reliably detect poor prognostic clones.