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This investigation demonstrated a novel TRIM59 gene as a multiple tumour marker for early diagnosis of tumorigenesis.
We assume that TRIM59 as an early Ras signal pathway effector may possibly act as a multiple tumour marker.
The use of quantitative reverse transcription real-time PCR (qRT-PCR) for detecting multiple tumour marker mRNAs from blood is a highly sensitive method.
TRIM59 may be used a novel multiple tumour marker for immunohistochemical detecting early tumorigenesis and could direct a novel strategy for molecular-targeted diagnosis and therapy of cancer.
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Once a genetic risk is confirmed, management is not consensual, but usually includes serial serum determinations of multiple tumour markers together with transvaginal ultrasound, another option being prophylactic oophorectomy after planned childbearing is completed.
To evaluate the importance of ID1 in malignant melanoma, tumour cell expression was examined by immunohistochemistry in 119 cases of nodular melanoma using tissue microarray technique, and related to multiple tumour markers including proliferation, p16 expression, angiogenesis and patient survival.
Single-cell detection and characterisation is limited owing to the technical difficulties of isolating adequate numbers of cells from the blood as well as the problems (both cost and optimisation time) in multiplexing antibodies against multiple tumour markers.
The simultaneous determination of the expression status of multiple, clinically relevant tumour markers could lead to a better detection of the primary tumour and its metastases, providing optimal tumour delineation during surgery under image guidance.
Due to the heterogeneity of head and neck tumours with different site specific prognosis and survival, the integration of multiple selected prognostic tumour markers in association with the histopathologic features is advocated for risk assessment.
MCM3 is overexpressed in multiple malignancies, regarded a more sensitive tumour marker than Ki67, and 90% of mice injected with MCM3 transfected cells developed epithelial tumours within 6 weeks[28].
Eligibility for HDCT with ASCR required a histologically or tumour marker proven germ cell tumour, multiple relapse and/or refraction to prior chemotherapy, a Karnofsky index ⩾60% and an age ⩾18 years.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com