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Moreover, the antitumour action of DR likely operates through multiple effects on the tumour cells and on the tumour associated host cells.
The ultimate goal is to provide multiple tumour-associated epitopes presented by both MHC class I and class II molecules.
Third, it may be worth developing broadly applicable vaccines that simultaneously target CTL to multiple tumour-associated epitopes (Graff-Dubois et al, 2002).
He presented data from a phase I study and a subsequent phase II study with renal cell carcinoma patients receiving a therapeutic vaccination against multiple tumour-associated peptides.
Recently, Walter et al (2012) reported the outcomes of phase I/II clinical trials using multiple tumour-associated peptides (TUMAPs) called IMA901.
Therefore, the inhibitory nature of lysates may be an inevitable consequence of their method of preparation, although lysates remain highly practical as a source of multiple tumour-associated antigens for clinical application.
TAM = tumour associated macrophage; TAN = tumour associated neutrophil; Treg = regulatory T cells.
CI = confidence interval; HR = hazard ratio; TAM = tumour associated macrophage; TAN = tumour associated neutrophil; Treg = regulatory T cells.
Loss of SDHB immunostaining has proved to be an important tool for recognising tumours associated with mutations in any of the SDHx genes, and indeed is a robust assay in all the multiple tumour types described above.
Relaxation of IGF2 imprinting in Wilms tumours associated with specific changes in IGF2 methylation.
We now demonstrate that genomic loss at DIAPH3 is associated with multiple tumour types, and that DIAPH3 resides at an important signalling node that controls the amoeboid phenotype.
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