However, with time, multiple subcutaneous tumors developed over the entire body, so it is possible that distant metastasis to vital organs, such as the lungs or liver, occurred.
Following repeated injections of CCl4, numerous relatively small tumors appeared in the markedly fibrotic and cirrhotic liver parenchyma, whereas in the DEN model, multiple large tumors developed in the non-cirrhotic background (Fig. 1a).
To determine and illustrate that the aggressive tumors developing in multiple metastatic sites were derived from the parental human SH-SY5Y cells, we karyotyped MSDACs, with and without characterized CD133+, and compared these with the parental cells.
They offer significantly reduced second primary cancer development after 32 months of follow-up, and multiple second primary tumors developed in the placebo group [ 64].
Another patient who underwent simultaneous treatment of multiple subcutaneous, inflamed tumors developed a "flare pain" reaction that lasted <4 h.
Tumors develop multiple potent and overlapping mechanisms to mediate immune evasion.
In typical transgenic mouse mammary models, tumorigenesis occurs in a multifocal manner, that is, multiple tumor foci develop in a mammary fat pad arising independently and at different starting times.
In this model, there is no "primary tumor", but tumor development mimics that of clinical metastatic neuroblastoma in that tumors develop in multiple anatomic locations including supra-renal and bone marrow.
In this model, there is no "primary tumor" but the pattern of tumor development recapitulates the clinical dissemination of high-risk NB; tumors develop in multiple anatomic locations including lung, liver and bone marrow [ 33, 34].
In addition, the model recapitulates the clinical pattern of metastatic neuroblastoma in that tumors develop in multiple loci, including the adrenal gland, bone marrow and liver.
