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Additional criteria were availability of multiple tumor blocks from the same case and treatment (N9831 specimens only).
Similar(58)
When available, tissue blocks from multiple tumor sections were assessed.
Smac-mimetic IAP-antagonists sensitize TRAIL-induced apoptosis by blocking XIAP function in multiple tumor models, including breast cancer [ 32], multiple myeloma [ 16], glioblastoma [ 11] and ovarian cancer [ 33].
If less than 9 eligible tumor containing blocks were available from the primary tumor, multiple punches were taken from one or several tumor blocks.
When possible, multiple blocks were used from the same tumor to a maximum of three tumor blocks per tumor.
Multiple ten micron (10 μm) thick sections from each of the FFPE cell line blocks, FFPE NSCLC xenograft tumor blocks, and the FFPE NSCLC patient tissue blocks were cut onto DIRECTOR® slides for tissue microdissection according to manufacturer's recommendations (Onco Plex Diagnostics Inc. Rockville, MD).
These images are the macroscopic histological images of tumor blocks.
It was difficult to distinguish multiple tumor from metastatic omental tumor in our case.
Tumor cells are sending messages to the stroma that keep the microenvironment inflamed and active; this "living shield" around a tumor blocks the access of immune cells and chemo drugs to the tumor.
Tumor blocks were obtained for 647 probands.
Tumor blocks from 149 patients were evaluable.
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