It is a heterogenous disease comprising multiple tumor entities associated with distinctive histological patterns, different biological features and clinical behaviors [ 2, 3].
Breast cancer comprises multiple tumor entities associated with different biological features and clinical behaviors, making individualized medicine a powerful tool to bring the right drug to the right patient.
Objective: There have been few series to report on the incidence of multiple primary tumors associated with hypopharyngeal cancer.
The impaired expansion of established autochthonous and transplantable tumors, the lacunar structure and increased permeability acquired by tumor vessels, perivascular tumor necrosis and the epitope spreading leading to induction of an immune response to tumor associated antigens are multiple features triggered by the vaccination against Amot.
In tumor microenvironment, tumor associated macrophage (TAM) is thought to have multiple functions of promoting tumor growth and metastasis, such as secreting growth factors and protease, promoting angiogenesis, and inhibiting adaptive immunity.
Recently, studies on dendritic cell (DC) vaccine have focused on the development of more effective DC vaccine regimen, such as the application of multiple tumor-associated antigen targeted DC vaccine.
Our recent studies demonstrated that a mini-array of multiple tumor-associated antigens (TAAs) might enhance autoantibody detection for diagnosis of HCC, especially for the alpha fetoprotein (AFP -negative cAFP -negative
Cases where cancer peptide vaccine preparations contain multiple tumor-associated antigens are envisioned.
CD8+ T cell responses to multiple tumor-associated antigens (TAA) were evaluated by IFN-γ-enzyme-linked immunosorbent spot (ELISPOT).
immatics' lead product, IMA901, a combination of multiple tumor-associated peptides (TUMAPs) for the treatment of renal cell carcinoma, commenced a world-wide phase 3 trial in 2011.
Generally, it is not considered necessary to evaluate the safety and activity of each component of peptide vaccine preparations containing multiple tumor-associated antigens; however, a case-by-case examination will be required.
