Multiple test procedures are often used in the analysis of clinical trials addressing multiple objectives, such as comparing several treatments with a control and assessing the benefit of a new drug for more than one endpoint.
The PainFREE trials address these issues.
All trials addressed clinically suspected VAP.
This topic should be addressed by a pooled analysis of multiple trials.
There are however no randomized controlled studies to address this issue and indirect comparisons from multiple trials are always limited by differences in baseline blood pressure and patient characteristics.
The SHINE trial addresses one primary objective and multiple secondary objectives (Table 1).
However, in a situation in which many CTN sites were participating in multiple trials, if a particular site consistently appeared close to the limit of the acceptance criterion, those findings could be addressed as a trend.
LaCoO3 was also shown to activate POMS for RB decolorization over multiple trials without losing efficiency.
Third, SEF neurons encoded trial outcomes both prospectively, before decisions within a trial, and retrospectively, across multiple trials.
Multiple trials were averaged.
