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Uncontrolled multiple trial data from over 300 SLE patients have been published from one centre suggesting a positive outcome; one single centre comparative study in 172 RA was positive.
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When studies included multiple trial arms, data on each intervention arm compared with the usual care arm were included in meta-analyses.
In the case of drugs with multiple clinical trial data available, the data from the source with the largest trial size first, and the highest incidence followed by the highest severity if the trial sizes were similar, were included for further analyses.
Time series in multivariate neural data are typically recorded from multiple electrodes and may include multiple trials of data.
In fact, the effect of ankle joint rotation during isometric contractions can be excluded in our experimental methodology, because the determination of V0 is based on the differences of ΔL obtained from the multiple trials (see Data analysis).
However, these effects are not substantiated in a recent meta-analysis of multiple trials with data available for HER2 and TOP2A [ 8].
The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2288/11/80/prepub The authors are grateful to the pharmaceutical company for providing the multiple sclerosis clinical trial data.
A good agreement is obtained between the model and experiment for multiple trial topologies of dimer (data not shown).
7 In ten (53%) meta-analyses, we found variability in pooled SMD results from trial data of multiple measurement scales used for the index outcome.
Good agreement is achieved between the model and the experimental data for multiple trial structures when only small oligomers are considered.
Analysis of individual participant data enabled the most complete, detailed, and in-depth analysis and was not more resource intensive than extracting, collating, and analysing aggregate data from multiple trial publications and conference abstracts.
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