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However, in our applied research we have routinely encountered study designs that do not conform to conventional power equations (e.g. multiple treatment interventions, where one treatment is deployed at the group level and a second at the individual level).
The method is universally applicable to a broad range of outcomes and designs, and it easily accommodates complex design features such as different follow-up plans, multiple treatment interventions, or different site-specific cluster effects.
Implementing any intervention in a standard format across sites is not straightforward but standardising complex, multiple treatment interventions, which may have a number of interacting components, is difficult and, some researchers argue, standardising the form of an intervention rather than its function may not be appropriate [ 18].
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Most studies used either an intra-articular or intramuscular route of administration in patients with refractory pain, who had not responded to multiple other treatment interventions.
A usual case has been defined as a common case such as non-specific low back pain where there are multiple possible treatment interventions, and where the best intervention needs to be identified.
Traditional meta-analyses are limited to comparing just 2 interventions concurrently and cannot combine evidence concerning multiple treatments.
Network meta-analysis (NMA), also called multiple treatments meta-analysis or mixed treatment comparison, is an extension of the traditional pairwise meta-analysis that enables comparisons between multiple interventions simultaneously, 6 respecting the randomization in the evidence.
Successful extermination can require multiple treatments.
If the disorder has multiple causes, then there should be multiple treatments.
Moreover, clinical trials generally test the efficacy of a single intervention, while, in daily practice, the best clinical benefit normally requires the combination of multiple treatments.
Trials including multiple treatments at the same time in the same group or comparing variants of the same intervention were excluded.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com