Sentence examples for multiple transgenic models from inspiring English sources

Moreover, an integrated gene signature from multiple transgenic models of epithelial cancers intrinsic to the functions of the Simian virus 40T/t-antigens is composed of genes regulating cell replication, proliferation and DNA repair.

Direct evidence that ABCA1-mediated lipidation influences amyloid degradation has been demonstrated in multiple transgenic models of AD.

A copper chelator known as diacetylbis(N(4 -methylthiosemicarbazonato) copper II (CuATSM), has been reported to be efficacious in multiple transgenic SOD1 models of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder affecting motor neurons.

Multiple transgenic mouse models have been developed based on overexpression of SNCA, each with advantages and limitations [45], [46].

Mild inhibition of complex I mitigates cognitive and behavioral decline in multiple transgenic animal models of AD.

For example in C. elegans, the most widely studied model organism in this context, multiple tissue-specific transgenic models manifesting pathological phenotypes that faithfully recapitulate many cellular and molecular pathologies of complex neurodegenerative disease processes have been used [ 5, 6].

Over the last decade a prominent amount of studies in preclinical transgenic models of multiple system atrophy (MSA) has been performed.

MJFF is currently generating and evaluating transgenic models in multiple species and also exploring the viral vector approach of introducing pathogenic mutations in vivo to induce neurodegeneration in PD-relevant brain pathways.

Multiple transgenic lines for each transgene were examined for fluorescence expression, rescue and/or localization patterns.

Although these conditional approaches overcome the adverse effects on development, they still require the generation of multiple transgenic or conditionally-inactivated strains to accurately model tumors.

For the mouse model this can be expensive in animal usage since variable copy-numbers of the transgene and integration positional effects require multiple transgenic lines in order to establish reproducible expression patterns.