Sentence examples for multiple transgenic mice from inspiring English sources

Bigenic and multiple transgenic mice expressing various combinations of mutant APP and mutant tau recapitulate the combined amyloid and tau-pathology of AD, but lack neurodegeneration and brain-atrophy typical for AD [14] [18].

To that end, multiple transgenic mice lacking K8/K18 or expressing mutated proteins are susceptible to a variety of different liver stresses [ 4].

Multiple transgenic mouse models have been developed based on overexpression of SNCA, each with advantages and limitations [45], [46].

We used multiple transgenic mouse lines to test the role of distinct brainstem populations in generating and coordinating respiratory behaviors in mice.

For example, LaFerla and colleagues [ 38] developed multiple transgenic mouse lines over expressing human Aβ42 exclusively in the cytosol of neurons.

This discovery led to the generation of multiple transgenic mouse lines based on overexpression of the WT or mutated protein under various heterologous promoters (for a review see Chesselet and Richter, 2011).

In multiple studies transgenic mice over-expressing BCL2 in various target cells have decreased apoptosis and improved survival in sepsis [13], [15], [28], [29].

This would ultimately facilitate many areas of biomedical research that depend on rapid generation of multiple, reliable transgenic mice since it would address the major constraints such as time, costs and variable efficiencies associated with the use of ES cell-based targeted transgenesis approach while taking care of several pitfalls associated with random transgenesis approaches.

Multiple strains of transgenic mice carrying high copy numbers of the human CD3ε (hCD3ε) genomic sequence exhibit inhibited development of T cells and natural killer cells [1].

Nowadays, multiple strains of transgenic mice with mutations of the peptide amyloid precursor protein (APP) have been developed.

To circumvent the problems inherent in transgenic mouse studies, analysis of multiple lines of transgenic mice with different copy numbers is necessary.