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In addition, the rapid responses to hypoxia are mediated by multiple transduction pathways activated also upon GPER stimulation [ 67, 68].
Expression analyses suggested that maize CDPK genes are important components of maize development and multiple transduction pathways.
In response to different signals, multiple transduction pathways and targets are activated to induce cellular senescence responses.
Ionizing radiation produces several types of cellular response via activation of multiple transduction pathways resulting in cell death, differentiation, or proliferation.
GSK-3 is a kinase crucially involved in a variety of biological processes; it targets more than 50 substrates, and it is placed at the crossroads of multiple transduction pathways, in multimeric complexes with scaffold proteins, other kinases and substrates.
In order to search a dominant target for therapy, it should be taken into account that PC is a heterogeneous disease in which multiple transduction pathways may interact in the uncontrolled apoptosis/cell proliferation.
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Moreover, the existence of multiple G-type proteins in sensory epithelium suggests that multiple signal transduction pathways may be activated following ligand stimulus.
Multiple signal transduction pathways, involving a range of signalling molecules, determine the effects of TGF-β influence on multiple aspects of tumour growth and progression.
The alpha-chemokine, stromal cell-derived factor-1alpha, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways.
These data are novel observations showing that Stxs regulate multiple signal transduction pathways controlling translation in host cells, and support a role for eIF4E phosphorylation in maintaining host cell translation despite ribosomal intoxication.
The TJ disruption has been related to multiple signal transduction pathways; understanding such mechanisms in hypoxia induced disruption of epithelial and endothelial barrier functions is likely to provide insight into the pathogenesis of various inflammatory diseases, and may form a basis for the design of treatment strategies for different diseases involving barrier dysfunction.
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