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In rat, two functional genes are reported for S27; multiple transcripts encode each isoform and exhibit different tissue expression patterns [ 48].
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SOD2-deficiency had profound effects on transcription of genes involved in mitochondrial metabolism, with multiple transcripts encoding proteins involved in oxidative phosphorylation, ATP synthesis, TCA cycle and mitochondrial biogenesis down-regulated in Sod2-/ erythroblasts (figure 3).
Syp associates with multiple transcripts encoding key synaptic regulators, as well as many mRNAs encoding proteins of unknown function.
CHMP2B cases show downregulation in multiple transcripts encoding proteins involved in the transport of cargoes along microtubules, suggesting impairments in axonal transport (KIF1A, KIF1C, KIF5C DYNLL21, DYNLL2 and DYNC1H1), a phenomenon that has been well documented in multiple neurodegenerative diseases, including a SOD1-mediated model of ALS [55].
Alternative splicing is emerging as a major molecular mechanism to extend the repertoire of functions produced by individual genes, through the expression of multiple transcripts encoding proteins with different biochemical and physical properties, and to diversify the regulation of their expression through alternative 5' and 3'UTRs.
Here, we found multiple transcripts encoding anthocyanidin glucosyltransferase and anthocyanin acyltransferase in the database.
Multiple transcripts encoding proteins involved in heat-shock were observed to be down regulated in Wolbachia-infected S2 cells.
Multiple transcripts encoding almost all known enzymes involved in flavonoid biosynthesis were identified in the annotated cranberry fruit transcriptome.
In our annotated C. sinensis transcriptome dataset, multiple transcripts encoding almost all known enzymes involved in the main flavonoid biosynthesis pathway were identified.
Therefore, multiple transcripts encoding for genes of the same protein family or protein complex were summed and represented as RPKM/protein (Additional file 1: Table S3).
In our annotated tea and oil tea transcriptome dataset, multiple transcripts encoding all DEGs involved in flavonoid, theanine and caffeine biosynthesis pathways were identified.
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