Sentence examples for multiple transcripts and from inspiring English sources

The initial promise of being able to transiently shut down expression of any gene soon gave way to reality, as researchers discovered that their synthetic siRNAs often targeted multiple transcripts, and often lacked the potency of more traditional drugs.

Certain genes correspond to multiple transcripts, and in terms of transcripts, our data consists of 98 pairs with 123 unique transcripts.

Multiple transcripts and corresponding proteins exist for VPS9D1.

More than 90% of human genes are estimated to be alternatively spliced, producing multiple transcripts and (often) different protein sequences from a single locus.

By targeting multiple transcripts and affecting expression of numerous proteins, miRNAs are capable of fine-tuning diverse cellular functions, including development, differentiation, proliferation, apoptosis and metabolism [ 2].

Both genes are represented by multiple transcripts and have a GC content typical for K. brevis nuclear encoded genes (Table 2).

Since multiple transcript and protein variants expressed by the same gene are, by definition, structurally distinct and need not to be functionally equivalent, the concept of gene orthology should be extended to the transcript level in order to describe evolutionary relationships between structurally similar transcript variants.

Among the upregulated transcripts in HeLa cells (n = 244) and HEK293 (n = 226), multiple transcripts (95 and 44, respectively) corresponded to ER substrates, indicating that there is a large number of transcripts processed in the ER that are regulated by the NMD mechanism.

The potent suppression of a single gene transcript using electroporation prompted us to examine whether this approach would be useful for targeting multiple transcripts simultaneously and thereby enable the perturbation of multiple interacting gene products in the RB and p53 pathways.

These included 29 transcripts for WRKY domain proteins, and multiple transcripts for PTI5, RAV, NAC and MYB-like transcription factors, some of which are known to be transcriptional regulators of various disease responses [ 48- 50].

In conclusion, by refining the accuracy of prediction regarding single and multiple transcript genes and evidence for their expression the transcriptome sequencing improved the annotation of the C. floridanus proteome, the identification of repetitive elements as well as alternative splicing predictions.