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TP63 is a complex gene that has multiple transcriptional isoforms, some of which are tumor suppressors (the TP63 isoforms), while the others are oncogenes (ΔTP63; dNTP63) [11].The TATP63 isoforms can bind to DNA through p53-responsive elements and therefore "p53-like".
This is the first time that multiple transcriptional isoforms of most myofibrillar proteins have been identified in tarantula (Table 1).
We identified, after excluding non-annotated genes and multiple transcriptional isoforms, 237 annotated genes that were significantly differentially expressed (p-value with FDR <0.05 and a fold change >2) between BRAFwt and BRAFmut PTCs (Additional file 1).
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By increasing the proportion of genes that express multiple transcript isoforms, C. elegans operons may compensate for a more strict transcriptional regulation and achieve the goal of expression complexity.
Redundancies due to annotation of multiple transcript isoforms were filtered.
Transcriptional isoforms are not just random combinations of exons.
However, transcriptional isoforms may be not just random combinations.
We have also characterized the different transcriptional isoforms and their tissue specific expression in the mouse.
Currently, however, identification and quantification of individual transcriptional isoforms is a major challenge.
However, the 3'UTR had several insertions, indicating that there are two transcriptional isoforms of TnC.
It is tightly regulated by multiple transcriptional and posttranscriptional mechanisms.
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