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A majority of these households are located in poor rural communities and burn such solid fuels in inefficient devices, often in kitchens that are poorly ventilated, resulting in very high exposures to multiple toxic products of incomplete combustion (1).
The high prevalence of solid cookfuel use (such as biomass and coal) for household energy needs in poor communities of developing countries [ 1, 2] has been known to result in exposures to multiple toxic products of incomplete combustion and is amongst the leading environmental risk factors contributing to the global burden of disease [ 3, 4].
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These multiple HNE adducts may rearrange to form other toxic products, or by corollary, this could be one of the in vivo homeostatic mechanisms to detoxify lipid oxidation products by effectively quenching HNE's reactivity.
Another possibility is that the lesions were a consequence of the concentration of the possibly toxic products resulting from the coalescence of multiple small phagolysosomes with their contents.
It is an effort to develop an Au nanostructure-based electrochemical sensor platform for the sensitive detection of multiple toxic analytes such as hydrazine, sulfite, and nitrite, which usually exist in food products and environment.
The many observed adverse effects are not surprising, given the diversity of fossil fuel combustion products (Bernard et al. 2001); moreover, the same pollutant can exert multiple toxic effects.
"World's Toxic Trash Bin: India Accepting Toxic Products from Industrialized Nations". India Currents Magazine, 13 July 1995.
Why spend money on more potential toxic products that might or might not work?
In conclusion, by combining the toxic-response gene SERPINB2 and human stem cells, we can develop an in vitro screening platform for multiple toxic substances.
Manufacturers of toxic products often don't make it any easier to prevent such incidents.
And they were overwhelmed by the Wall Street firms churning out their toxic products.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com