Sentence examples for multiple toxic pathways from inspiring English sources

Therefore, designing compounds that can inhibit multiple toxic pathways is the most attractive therapeutic strategy in complex disorders like AD.

Data from nine microarray experiments that evaluated the effect of multiple toxic agents on mouse (Mus musculus) embryo gene expression levels were used to reconstruct the adherens junction pathway.

Moreover, transcripts related to these toxic pathways were also significantly affected by BT.

AR cells lacked expression of multiple toxic BH3 domain proteins and had increased expression of c-FLIP-s, resulting in an inherent reduction in the ability of either the intrinsic or extrinsic apoptosis pathways from being engaged.

It is unlikely that single end point hormesis would be quantitatively useful for toxics expressing multiple toxic effects in multiple organs and through multiple mechanisms.

Cd is a potential carcinogenic agent and has multiple toxic effects in cadmium-associated diseases.

Not surprisingly, these therapies have multiple toxic side effects (reviewed in [ 2]).

Hormesis does not accommodate multiple toxic end points, target organs or mechanisms.

Oxidative stress is thought to be a critical node in the toxic pathway for numerous diseases.

Exposures to poly-chlorinated dibenzo- p-dioxins (PCDDs), polychlorinated biphenyls (PCBs), and poly-chlorinated dibenzofurans (PCDFs), which are products and by-products of industrial or combustion processes, have the potential to disrupt multiple endocrine pathways and induce toxic responses.

Therefore, it is highly desirable to search for new therapeutic moieties which can simultaneously treat multiple aberrant pathways yet being less toxic and inexpensive.