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Cd is a potential carcinogenic agent and has multiple toxic effects in cadmium-associated diseases.
Presently, such neoadjuvant therapies relay mostly on cytotoxic chemotherapies which, unfortunately, have limited efficacy, as well as multiple toxic effects.
Severe hyperbilirubinemia is known to exert multiple toxic effects, but there are very little tools against the bilirubin intoxication.
It is unlikely that single end point hormesis would be quantitatively useful for toxics expressing multiple toxic effects in multiple organs and through multiple mechanisms.
Trichothecenes exert multiple toxic effects on eukaryotic cells, including inhibition of protein synthesis, cytotoxicity, and apoptosis (Rocha et al. 2005; Rotter et al. 1996).
In all cases but two, patients had multiple toxic effects of grade 2 and/or 3. Sunitinib was discontinued and resumed either at the same dose in three cases (16.5%) or at a lower dose in eight cases (44.5%).
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Other research points towards a 'toxic RNA' hypothesis (Haeusler et al., 2014; Lee et al., 2013) and current thinking in the field often refers to the possibility of a multiple toxic effect of both the mutant protein and RNA.
The two major types of rhabdomyosarcoma (RMS) are predominantly diagnosed in children, namely embryonal (ERMS) and alveolar (ARMS) RMS, and patients are treated with cytotoxic drugs, which results in multiple toxic side effects later in life.
Not surprisingly, these therapies have multiple toxic side effects (reviewed in [ 2]).
Polycyclic aromatic hydrocarbons, such as 7,12-dimethylbenz[a]anthracene (DMBA), are environmental pollutants that exert multiple toxic and carcinogenic effects [ 4].
To identify conditions that maximise transfection efficiency and minimise lipid-mediated toxic effects, multiple transfection conditions for each cell line were tested.
More suggestions(15)
multiple toxicological effects
multiple toxic mediators
multiple toxic agents
multiple toxic analytes
multiple neuroprotective effects
multiple untoward effects
multiple toxic substances
multiple toxic phenomena
multiple toxic products
multiple toxic pathways
multiple toxic drugs
multiple toxic elements
multiple toxic metal
multiple toxic mycotoxins
multiple toxic therapies
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