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Therefore, although most ribosomal protein genes could be called housekeeping genes, there was significant variation in expression across multiple tissues which indicated that these genes cannot be used in all conditions as reference genes.
Therefore, hSAGEing is novel in its use of multiple simultaneous comparisons of SAGE libraries (such as cancer vs. normal tissue comparisons over multiple tissues) which increase its efficiency over existing software.
Nearly all of the detected non-vertebrate organisms had alignments from multiple tissues, which would be expected for blood-borne parasites.
Coho salmon (Oncorhynchus kisutch) transgenic for growth hormone (Gh) express Gh in multiple tissues which results in increased appetite and continuous high growth with satiation feeding.
An alternative approach is to use the average exonic expression level or the specificity of exonic expression (or exonic expression breadth) across multiple tissues, which are continuous variables and can be compared both within and between genes.
In turn, the central clock responds to these cues and coordinates behavioral and physiological changes across the dams by sending humoral and neural signals to multiple tissues, which stimulate changes in core molecular clocks of peripheral tissues including endocrine glands, mammary, and liver.
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If the gene for this phospholipase was not transcriptionally off most of the time, the gene product (phosphalipase A2) would be expected to promote decomposition of the cell membranes in multiple soft tissues, which under normal conditions would have a deleterious effect on cellular health.
We have previously studied specific behaviours in transgenic male CD-1 mice mice, which overexpress the gene encoding human transforming growth factor alpha (TGF alpha) in multiple tissues, and which develop a high incidence of spontaneous hepatocellular carcinoma.
Microscopic examination of paraffin-embedded tissue sections revealed that the part of the mass attached to the testis contained fibrous tissue with multiple foci of nephrogenic tissues, which were composed of immature glomeruli, tubules and blastemal cells.
The dominant reason of limiting the imaging depth and contrast in optical imaging within therapeutic and diagnostic optical window is multiple scattering in biological tissues, which is mostly contributed by refractive index mismatch [ 2].
This assumption is, however, typically not valid: many disease-associated genes are expressed in multiple tissues, most of which do not show pathophysiological manifestations of the disease or of any functional abnormality1,2.
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