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We examine the potential for a broad range of small animal cells, including rodent, mink, and avian cells, from multiple tissues to support postintegration steps of HIV-1 replication.
Again, we suspect multiple tissues to show variable phenotypes; this suspicion is based on the multiple functional roles reported for the AMPK molecule, and we have begun assessing starvation phenotypes in discrete tissues in Drosophila.
Clinical and animal studies suggest that PCOS has a developmental origin, in which androgen excess during fetal or prepubertal life reprograms multiple tissues to manifest the syndrome in adolescence and adulthood [22], [23].
In this study, we demonstrate the power of computational analysis of eQTL datasets across multiple tissues to provide new insights into the genome-wide correlation structure in gene expression data.
We examined HIV-1 C2-V5 sequences from multiple tissues to assess whether or not there was a restriction of HIV-1 gene flow between the lung and blood.
FGF21 acts as a hormone-like cytokine on multiple tissues to coordinate carbohydrate and lipid metabolism [ 4].
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KLHL9 was expressed in skeletal muscle and multiple tissues at moderate to high levels with the exception of liver, colon, small intestine, the thyroid gland, pancreas and uterus, where KLHL9 was expressed at low levels (Fig. 5B, Supplementary Table 1).
Experimental infection of immunocompromised severe combined immunodeficient (SCID) mice and nude mice, both deficient in adaptive immune responses, have shown much greater dissemination of HTNV and SEOV to multiple tissues compared to immunocompetent BALB/c mice [ 252] with the highest concentration of virus being found in the brain and kidneys.
This is in agreement with previous findings, which show that eQTL found in multiple tissues tended to localize closer to the TSS than tissue-specific eQTL [ 9].
However, in other cases, a systems level approach is required to understand how perturbations to gene-networks connecting multiple tissues lead to a phenotype.
We have generated and characterized a reference transcriptome for rainbow trout that represents multiple tissues responding to multiple stressors common to aquaculture production environments.
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