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While these data suggest a role for Sox2 in regulating embryonic differentiation in multiple tissues, the requirement for Sox2 in bronchiolar cells of the postnatal lung is unknown.
We identified only a few opposite allelic effects (<1%) between the tissues (Additional file 16A and B), suggesting that if a SNP affects expression in multiple tissues, the allelic direction is mostly identical.
Due to their diverse differentiation potentials, the relative ease of their isolation from multiple tissues, the fact that they can be expanded and multiplied in vitro, and their immunomodulatory properties, MSCs are regarded as a promising tool for clinical applications.
While the growing stem is a complex organ consisting of multiple tissues, the common denominator across all of these cell types is the coordinated and initially rapid anisotropic expansion of their cell walls along the axis of growth.
Analyses were performed in 283 healthy individuals for whom both whole blood DNA methylation levels and gene expression profiles from the multiple tissues (the lymphoblastoid cell lines (LCL), skin, and adipose) were available.
A range of HCMV features like its lytic replication in multiple tissues, the lifelong persistence through periods of latency and intermitting reactivation, the extraordinary large proteome, and extensive manipulation of adaptive and innate immunity make HCMV a high profile candidate for involvement in autoimmune disorders.
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The array was used to produce the Tobacco Expression Atlas (TobEA), which provides a snap-shot of gene expression from multiple tissues throughout the lifecycle of the tobacco plant.
In this study, we developed a new computational approach to predict RNA editing from multiple tissues in the absence of the genome information.
Immediately after the cessation of stress, multiple tissues from the other 16 animals were assayed for the amount of mtDNA and telomere length.
Specifically, the HMTs and the HDMs play important roles in multiple tissues regulating the methylation status of four lysine residues K4, K9, K27 and K36 on histone H3.
Regulatory guidance documents stress the value of assessing multiple tissues and the most appropriate endpoints when evaluating chemicals for in vivo genotoxic potential.
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