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However, a larger proportion of novel splice junctions are commonly detected in multiple tissues, indicating the prevalence of AS across tissues in the B. rapa genome.
Opsins of different types are expressed in multiple tissues, indicating that opsin-dependent photosensitivity is not restricted to the eyes or the central nervous system (CNS) [ 3- 5].
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Cloning, determining potential secondary structures and expression analysis of all new miRNAs in multiple tissues indicate their tissue specific existence and regulation of gene expression.
Northern blot analysis on multiple tissues indicated little to no increase in miR-29b in kidney or liver samples compared to saline control.
Therefore, although most ribosomal protein genes could be called housekeeping genes, there was significant variation in expression across multiple tissues which indicated that these genes cannot be used in all conditions as reference genes.
The low level of etv7 expression in multiple tissues might indicate a fundamental role of etv7 during both development and adulthood.
Knockout mouse studies have demonstrated the tumor suppressive role of PTEN in multiple tissues, and indicate that PTEN function is gene-dosage dependent, as subtle changes in PTEN protein expression level yield significant functional consequences in terms of tumor growth and progression [ 46, 47].
The maintenance of low levels of p38α activity regulates the progression of the AP in multiple tissues, as indicated by the improved regenerative capacity of aged skeletal muscle progenitor cells treated with inhibitors of p38α/β activity [ 8, 9] and the prolonged capacity of aged pancreatic β-cells to proliferate in response to injury by streptozotocin [ 24].
Expression profiling for multiple human and mouse tissues indicates correlations between expression of certain Rabs and the SNAREs, adaptors, and other proteins with which they interact [ 17] and facilitates construction of potential interaction hubs and prediction of novel pathways.
The frequent silencing of OPCML-v1 in multiple tumor cell lines and primary tumors but not normal epithelial tissues indicates that OPCML-v1 is likely a tumor suppressor.
These data from different tissues indicates that CNX-012-570 improves whole body insulin sensitivity through multiple mechanisms.
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