ILC3s have also been implicated in tissue repair following inflammation or damage in multiple tissues, including intestines, thymi, and lungs (Dudakov et al., 2012; Sawa et al., 2011; Taube et al., 2011).
We demonstrate the broad applications of this mouse by examining E-cadherin regulation in multiple tissues, including mammary, brain, liver, and kidney tissue, while specifically monitoring E-cadherin mobility during disease progression in the pancreas.
In subsequent years, the use of other NSAIDs, which inhibit cyclooxygenase (COX) enzymes, was linked to reduced cancer risk in multiple tissues including those of the breast, prostate, and lung.
Cerebrotendinous xanthomatosis is a progressive neurodegenerative storage disease caused by recessive CYP27A1 mutations and is characterized by abnormal deposition of cholestanol and cholesterol in multiple tissues, including the lens and brain.
Interestingly, transmembrane-type spinesin, types 3 and 4, was specifically expressed in the spinal cord, whereas cytoplasmic type, type 1, was expressed in multiple tissues, including the cerebrum and cerebellum.
Symatlas data were considered most useful for this study as it provides the largest publicly accessible data collection on multiple tissues, including both adult and fetal tissues.
An anti-RME-1 polyclonal serum detects RME-1 in a punctate pattern in multiple tissues including the germline and intestine [70].
Increased Ctgf expression is clearly associated with fibrosis in multiple tissues including skin, liver, heart, lung, and kidney (reviewed in [11], [12]).
Interestingly, our analysis identified 14 genes that Ivanova et al [25] reported as genes expressed in stem cells from multiple tissues including HSC, ESC and NSC (Table S2B).
As a positive control we included measurement of GILZ mRNA [20] which was up-regulated in multiple tissues, including lung (Figure 3A), liver (Figure 3B), kidney (Figure 3C), spleen (Figure 3D) and brain (Figure 3E) [21].
